The relationship between fiber intake and fat composition and hormone profile in women with central obesity

Lintang Mega Pertiwi* -  Faculty of Dentistry, Kadiri University, Kediri, Jawa Timur, Indonesia
Ibnu Gunawan -  Faculty of Dentistry, Kadiri University, Kediri, Jawa Timur, Indonesia
DOI : 10.30867/action.v10i4.2876

Central obesity is characterized by increased visceral and subcutaneous fat and is associated with metabolic and hormonal disturbances in women. This study aimed to analyze the relationship between dietary fiber intake and visceral fat, subcutaneous fat, and sex hormone–binding globulin (SHBG) levels in women with central obesity. A cross-sectional study was conducted in the Kediri Raya region in August 2025. The sample consisted of 70 women aged 19–45 years with a waist circumference greater than 80 cm, selected through purposive and quota sampling methods. A Semi-Quantitative Food Frequency Questionnaire was used to assess fiber intake. Visceral and subcutaneous fat were measured using Bioimpedance Analysis, and SHBG levels were obtained from blood samples. Statistical analyses included Pearson’s correlation, Fisher’s exact test, and multivariate linear regression adjusted for energy and macronutrient intakes. The results showed that fiber intake was significantly associated only with age (p= 0.026), but not with BMI, visceral fat, subcutaneous fat, or SHBG (p > 0.05). Multivariate analysis indicated that the carbohydrate–fiber interaction was negatively associated with BMI (p= 0.038) and visceral fat (p= 0.011). Conversely, fat–fiber interactions were positively associated with BMI (p= 0.008), visceral fat (p= 0.006), and subcutaneous fat (p= 0.035). No significant association was found between fiber intake and SHBG levels (p > 0.05). In conclusion, fiber intake in interaction with macronutrients influenced BMI and body fat composition but did not affect SHBG levels, highlighting the role of nutrient interactions in shaping visceral and subcutaneous fat tissue.

Keywords : Dietary fiber, obesity abdominal, subcutaneous fat, sex hormone-binding globulin, visceral fat

  1. Ahmed, B., Sultana, R., & Greene, M. W. (2021). Adipose tissue and insulin resistance in obese. Biomedicine & Pharmacotherapy, 137, 111315. https://doi.org/10.1016/j.biopha.2021.111315
  2. Alwash, S. M., McIntyre, H. D., & Mamun, A. (2021). The association of general obesity, central obesity and visceral body fat with the risk of gestational diabetes mellitus: Evidence from a systematic review and meta-analysis. Obesity Research & Clinical Practice, 15(5), 425–430. https://doi.org/10.1016/j.orcp.2021.07.005
  3. Antunes, M. M., Godoy, G., de Almeida-Souza, C. B., da Rocha, B. A., da Silva-Santi, L. G., Masi, L. N., Carbonera, F., Visentainer, J. V., Curi, R., & Bazotte, R. B. (2020). A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle. Brazilian Journal of Medical and Biological Research, 53, e9039. https://doi.org/10.1590/1414-431X20199039
  4. Anwer, R., Baig, L. A., & Musharraf, M. (2023). Validation of HF-Bioelectrical Impedance Analysis versus Body Mass Index in classifying overweight and obese Pakistani adults. Journal of Multidisciplinary Healthcare, 16, 983–996. https://doi.org/10.2147/JMDH.S378367
  5. Bahreynian, M., Qorbani, M., Motlagh, M. E., Riahi, R., & Kelishadi, R. (2018). Association of dietary fiber intake with general and abdominal obesity in children and adolescents: The Weight Disorder Survey of the CASPIAN-IV Study. Mediterranean Journal of Nutrition and Metabolism, 11(3), 251–260. https://doi.org/10.3233/MNM-180224
  6. Bernstein, L. E., Rohr, F., & Van Calcar, S. (2022). Nutrition management of inherited metabolic diseases: Lessons from Metabolic University. Springer Nature.
  7. Brianso-Llort, L., Saéz-Lopez, C., Alvarez-Guaita, A., Ramos-Perez, L., Hernandez, C., Simó, R., & Selva, D. M. (2024). Recent advances on sex hormone-binding globulin regulation by nutritional factors: Clinical implications. Molecular Nutrition & Food Research, 68(14), 2400020. https://doi.org/10.1002/mnfr.202400020
  8. Christiansen, M. R., Kilpeläinen, T. O., & McCaffery, J. M. (2023). Abdominal obesity genetic variants predict waist circumference regain after weight loss. Diabetes, 72(10), 1424–1432. https://doi.org/10.2337/db23-0131
  9. Dominguez, L. J., Veronese, N., Di Bella, G., Cusumano, C., Parisi, A., Tagliaferri, F., Ciriminna, S., & Barbagallo, M. (2023). Mediterranean diet in the management and prevention of obesity. Experimental Gerontology, 174, 112121. https://doi.org/10.1016/j.exger.2023.112121
  10. Fauziyana, N., Prafiantini, E., & Hardiany, N. S. (2022). Pattern of fiber intake in different socio-demographic settings among elderly in Jakarta, Indonesia and its associated factors. World Nutrition Journal, 4(2), 1–9. https://doi.org/10.25220/WNJ.V04.i2.0002
  11. Getahun, M. S., Deybasso, H. A., Komicha, M. A., & Gurara, A. M. (2023). Magnitude of central obesity and associated factors among adult patients attending public health facilities in Adama town, Oromia region, Ethiopia, 2022. Journal of Health, Population, and Nutrition, 42(1), 57. https://doi.org/10.1186/s41043-023-00397-z
  12. Guasch-Ferré, M., & Willett, W. C. (2021). The Mediterranean diet and health: A comprehensive overview. Journal of Internal Medicine, 290(3), 549–566. https://doi.org/10.1111/joim.13333
  13. Handayani, M., Putri, N. A., Hasniyati, R., & Sidiq, R. (2025). Central obesity incidence in adult women. ResearchGate. https://doi.org/10.18535/ijmsci/v7i11.09
  14. Hasibuan, M. U. Z., & A, P. (2021). Sosialisasi penerapan Indeks Massa Tubuh (IMT) di Suta Club: Socialization of the application of Body Mass Index (IMT) at Suta Club. Jurnal Cerdas Sifa Pendidikan, 10(2), 84–89. https://doi.org/10.22437/csp.v10i2.15585
  15. He, Y., Wang, B., Wen, L., Wang, F., Yu, H., Chen, D., Su, X., & Zhang, C. (2022). Effects of dietary fiber on human health. Food Science and Human Wellness, 11(1), 1–10. https://doi.org/10.1016/j.fshw.2021.07.001
  16. Islam, F., Kathak, R. R., Sumon, A. H., & Molla, N. H. (2020). Prevalence and associated risk factors of general and abdominal obesity in rural and urban women in Bangladesh. PLOS ONE, 15(5), e0233754. https://doi.org/10.1371/journal.pone.0233754
  17. Johnson, C., Garipoğlu, G., Jeanes, Y., Frontino, G., & Costabile, A. (2025). The role of diet, glycaemic index and glucose control in polycystic ovary syndrome (PCOS) management and mechanisms of progression. Current Nutrition Reports, 14(1), 8. https://doi.org/10.1007/s13668-024-00601-4
  18. Kemenkes, R. (2013). Katalog data—Layanan permintaan data | Kementerian Kesehatan RI. https://layanandata.kemkes.go.id/katalog-data/riskesdas/ketersediaan-data/riskesdas-2013
  19. Kemenkes, R. (2018). Katalog data—Layanan permintaan data | Kementerian Kesehatan RI. https://layanandata.kemkes.go.id/katalog-data/riskesdas/ketersediaan-data/riskesdas-2018
  20. Kemenkes, R. (2023). Laporan SKI 2023 dalam angka (Revisi I). Google Docs. https://drive.google.com/file/d/1rjNDG_f8xG6-Y9wmhJUnXhJ-vUFevVJC/view
  21. Kerkadi, A., Sadig, A. H., Bawadi, H., Al Thani, A. A. M., Al Chetachi, W., Akram, H., Al-Hazzaa, H. M., & Musaiger, A. O. (2019). The relationship between lifestyle factors and obesity indices among adolescents in Qatar. International Journal of Environmental Research and Public Health, 16(22), 4428. https://doi.org/10.3390/ijerph16224428
  22. Khatun, M., Lundin, K., Naillat, F., Loog, L., Saarela, U., Tuuri, T., Salumets, A., Piltonen, T. T., & Tapanainen, J. S. (2024). Induced pluripotent stem cells as a possible approach for exploring the pathophysiology of polycystic ovary syndrome (PCOS). Stem Cell Reviews and Reports, 20(1), 67–87. https://doi.org/10.1007/s12015-023-10627-w
  23. Liu, M., Jia, C., Hu, Y., Liu, J., Liu, L., Sun, S., Wang, H., & Liu, Y. (2024). Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China. Preventive Medicine Reports, 40, 102673. https://doi.org/10.1016/j.pmedr.2024.102673
  24. Luo, J., & Lin, S. (2023). Longitudinal influence of dietary fiber intake and ovarian hormones on body mass index trajectories in midlife women: The Study of Women’s Health Across the Nation. Research Square. https://doi.org/10.21203/rs.3.rs-3350274/v1
  25. Markovikj, G., Knights, V., & Kljusurić, J. G. (2023). Ketogenic diet applied in weight reduction of overweight and obese individuals with progress prediction by use of the modified Wishnofsky equation. Nutrients, 15(4), 927. https://doi.org/10.3390/nu15040927
  26. Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A. (2023). Mechanisms of oxidative stress in metabolic syndrome. International Journal of Molecular Sciences, 24(9), 7898. https://doi.org/10.3390/ijms24097898
  27. McGaugh, E., & Barthel, B. (2022). A review of ketogenic diet and lifestyle. Missouri Medicine, 119(1), 84–88.
  28. Melyana, C. P., Rejeki, P. S., Mudjanarko, S. W., Herawati, L., & Al-Arif, M. A. (2021). Effect of high fat diet on body weight, visceral fat weight, and PPARG expressions on visceral fat in mice. Folia Medica Indonesiana, 57(3), 186–191. https://doi.org/10.20473/fmi.v57i3.16213
  29. Ntimana, C. B., & Choma, S. S. R. (2023). Modifiable determinants of central obesity among the rural black population in the DIMAMO HDSS, Limpopo, South Africa. Frontiers in Public Health, 11, 1165662. https://doi.org/10.3389/fpubh.2023.1165662
  30. Nursabrina, A. L. (2025). Validasi SQ-FFQ dengan estimated food record untuk menilai jumlah asupan buah sayur dan zat gizi mikro mahasiswa. Jurnal Ilmu Kesehatan dan Gizi, 3(2), 147–156. https://doi.org/10.55606/jig.v3i2.4294
  31. Obesity and overweight. (2024). World Health Organization. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  32. Sun, Y., Li, S., Liu, H., Bai, H., Hu, K., Zhang, R., Liu, Q., & Fan, P. (2021). Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome. Fertility and Sterility, 116(6), 1641–1650. https://doi.org/10.1016/j.fertnstert.2021.07.1203
  33. Szybiak-Skora, W., Cyna, W., & Lacka, K. (2025). New insights in the diagnostic potential of sex hormone-binding globulin (SHBG)—Clinical approach. Biomedicines, 13(5), 1207. https://doi.org/10.3390/biomedicines13051207
  34. Wang, B., Kong, Q., Li, X., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2020). A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference. Nutrients, 12(10), 3197. https://doi.org/10.3390/nu12103197
  35. Wang, Y. (2021). Definition, prevalence, and risk factors of low sex hormone-binding globulin in US adults. The Journal of Clinical Endocrinology & Metabolism, 106(10), e3946–e3958. https://doi.org/10.1210/clinem/dgab438
  36. Wong, M. C. S., Huang, J., Wang, J., Chan, P. S. F., Lok, V., Chen, X., Leung, C., Wang, H. H. X., Lao, X. Q., & Zheng, Z.-J. (2020). Global, regional and time-trend prevalence of central obesity: A systematic review and meta-analysis of 13.2 million subjects. European Journal of Epidemiology, 35(7), 673–683. https://doi.org/10.1007/s10654-020-00650-3
  37. World Obesity Atlas 2023. (2023). World Obesity Federation. https://www.worldobesity.org/resources/resource-library/world-obesity-atlas-2023
  38. Xiao, Y., Liu, D., Cline, M. A., & Gilbert, E. R. (2020). Chronic stress, epigenetics, and adipose tissue metabolism in the obese state. Nutrition & Metabolism, 17(1), 88. https://doi.org/10.1186/s12986-020-00513-4
  39. Yusuf, A. N. M., Amri, M. F., Ugusman, A., Hamid, A. A., Wahab, N. A., & Mokhtar, M. H. (2023). Hyperandrogenism and its possible effects on endometrial receptivity: A review. International Journal of Molecular Sciences, 24(15), 12026. https://doi.org/10.3390/ijms241512026

Open Access Copyright (c) 2025 Lintang Mega Pertiwi, Ibnu Gunawan
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