Effectiveness of synbiotics in obesity management: A literature review
The increased occurrence of obesity worldwide is playing a major role in the growth of serious illnesses, such as Cardiovascular Disease and Type 2 diabetes. Modulation of gut microbiota using synbiotics is a novel alternative. This study provides evidence for the effectiveness of synbiotics in managing obesity, particularly with respect to body composition and anthropometric measurements. This review focuses on the years 2020-2025. Using the keywords “synbiotic” AND “obesity,” criteria based on inclusion and exclusion were applied to the Title, Abstract, and TEXT to screen publications. Data available in English in the specified years were used. Short-term synbiotic supplementation shows little evidence of affecting body weight or body mass index. However, waist circumference, body fat percentage, and visceral fat loss suggest that short-term to mid-term synbiotic supplementation has a more consistent effect on body composition and central obesity. The positive impact of synbiotics is more noticeable when high-fiber diets are used. In conclusion, ulterior to achieving absolute weight loss, it can be concluded that synbiotics are a safe means of managing obesity as a central means of improving body composition and central obesity.
Keywords : Anthropometry, body composition, gut microbiota, obesity, synbiotics
- Amabebe, E., Robert, F. O., Agbalalah, T., & Orubu, E. S. F. (2020). Microbial dysbiosis-induced obesity: Role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition, 123(10), 1127–1137. https://doi.org/10.1017/S0007114520000380
- Anggeraini, A. S., Massi, M. N., Hamid, F., Ahmad, A., As’ad, S., & Bukhari, A. (2021). Effects of synbiotic supplement on body weight and fasting blood glucose levels in obesity: A randomized placebo-controlled trial. Annals of Medicine & Surgery, 68, 102548. https://doi.org/10.1016/j.amsu.2021.102548
- Aoun, A., Darwish, F., & Hamod, N. (2020). The influence of the gut microbiome on obesity in adults and the role of probiotics, prebiotics, and synbiotics for weight loss. Preventive Nutrition and Food Science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113
- Atazadegan, M. A., Heidari-Beni, M., Entezari, M. H., Sharifianjazi, F., & Kelishadi, R. (2023). Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents: A randomized, double-blind, placebo-controlled clinical trial. World Journal of Pediatrics, 19(4), 356–365. https://doi.org/10.1007/s12519-022-00664-9
- Banach, K., Glibowski, P., & Jedut, P. (2020). The effect of probiotic yogurt containing Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12 on selected anthropometric parameters in obese individuals on an energy-restricted diet: A randomized, controlled trial. Applied Sciences, 10(17), 5830. https://doi.org/10.3390/app10175830
- Ben Othman, R., Ben Amor, N., Mahjoub, F., Berriche, O., El Ghali, C., Gamoudi, A., & Jamoussi, H. (2023). A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects. Endocrinology, Diabetes & Metabolism, 6(2), e402. https://doi.org/10.1002/edm2.402
- Chudzicka-Strugała, I., Kubiak, A., Banaszewska, B., Wysocka, E., Zwozdziak, B., Siakowska, M., Pawelczyk, L., & Duleba, A. J. (2024). Six-month randomized, placebo-controlled trial of synbiotic supplementation in women with polycystic ovary syndrome undergoing lifestyle modifications. Archives of Gynecology and Obstetrics, 311(2), 499–506. https://doi.org/10.1007/s00404-024-07833-3
- Da Silva, T. F., Casarotti, S. N., De Oliveira, G. L. V., & Penna, A. L. B. (2021). The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts. Critical Reviews in Food Science and Nutrition, 61(2), 337–355. https://doi.org/10.1080/10408398.2020.1733483
- Fallah, F., & Mahdavi, R. (2023). Ameliorating effects of L-carnitine and synbiotic co-supplementation on anthropometric measures and cardiometabolic traits in women with obesity: A randomized controlled clinical trial. Frontiers in Endocrinology, 14, 1237882. https://doi.org/10.3389/fendo.2023.1237882
- Hadi, A., Alizadeh, K., Hajianfar, H., Mohammadi, H., & Miraghajani, M. (2020). Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta-analysis of clinical trials. Critical Reviews in Food Science and Nutrition, 60(4), 584–596. https://doi.org/10.1080/10408398.2018.1545218
- Hassan, N. E., El-Masry, S. A., El Shebini, S. M., Ahmed, N. H., Mehanna, N. Sh., Abdel Wahed, M. M., Amine, D., Hashish, A., Selim, M., Afify, M. A. S., & Alian, K. (2024). Effect of weight loss program using prebiotics and probiotics on body composition, physique, and metabolic products: Longitudinal intervention study. Scientific Reports, 14(1), 10960. https://doi.org/10.1038/s41598-024-61130-2
- Hijová, E. (2022). Synbiotic supplements in the prevention of obesity and obesity-related diseases. Metabolites, 12(4), 313. https://doi.org/10.3390/metabo12040313
- IDF. (2025). Diabetes atlas (11th ed.). http://diabetesatlas.org
- Jannah, M., Zetta, A. P., Kinasih, P., & Hasibuan, W. A. (2025). Sugar-sweetened beverages and obesity risk: A narrative review. Nurish, 1(1). https://doi.org/10.37253/nurish.v1i1.11766
- Kassaian, N., Feizi, A., Aminorroaya, A., & Amini, M. (2019). Probiotic and synbiotic supplementation could improve metabolic syndrome in prediabetic adults: A randomized controlled trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(5), 2991–2996. https://doi.org/10.1016/j.dsx.2018.07.016
- Laue, C., Papazova, E., Pannenbeckers, A., & Schrezenmeir, J. (2023). Effect of a probiotic and a synbiotic on body fat mass, body weight and traits of metabolic syndrome in individuals with abdominal overweight: A human, double-blind, randomised, controlled clinical study. Nutrients, 15(13), 3039. https://doi.org/10.3390/nu15133039
- Lauw, S., Kei, N., Chan, P. L., Yau, T. K., Ma, K. L., Szeto, C. Y. Y., Lin, J. S.-C., Wong, S. H., Cheung, P. C. K., & Kwan, H. S. (2023). Effects of synbiotic supplementation on metabolic syndrome traits and gut microbial profile among overweight and obese Hong Kong Chinese individuals: A randomized trial. Nutrients, 15(19), 4248. https://doi.org/10.3390/nu15194248
- Muñoz-Cabrejas, A., Guallar-Castillón, P., Laclaustra, M., Sandoval-Insausti, H., & Moreno-Franco, B. (2023). Association between sugar-sweetened beverage consumption and the risk of the metabolic syndrome: A systematic review and meta-analysis. Nutrients, 15(2), 430. https://doi.org/10.3390/nu15020430
- Oraphruek, P., Chusak, C., Ngamukote, S., Sawaswong, V., Chanchaem, P., Payungporn, S., Suantawee, T., & Adisakwattana, S. (2023). Effect of a multispecies synbiotic supplementation on body composition, antioxidant status, and gut microbiomes in overweight and obese subjects: A randomized, double-blind, placebo-controlled study. Nutrients, 15(8), 1863. https://doi.org/10.3390/nu15081863
- Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019). Mechanisms of action of probiotics. Advances in Nutrition, 10, S49–S66. https://doi.org/10.1093/advances/nmy063
- Rabiei, S., Hedayati, M., Rashidkhani, B., Saadat, N., & Shakerhossini, R. (2019). The effects of synbiotic supplementation on body mass index, metabolic and inflammatory biomarkers, and appetite in patients with metabolic syndrome: A triple-blind randomized controlled trial. Journal of Dietary Supplements, 16(3), 294–306. https://doi.org/10.1080/19390211.2018.1455788
- Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019). Probiotics and prebiotics in intestinal health and disease: From biology to the clinic. Nature Reviews Gastroenterology & Hepatology, 16(10), 605–616. https://doi.org/10.1038/s41575-019-0173-3
- Santamarina, A. B., Moraes, R. C. M., Nehmi Filho, V., Murata, G. M., De Freitas, J. A., De Miranda, D. A., Cerqueira, A. R. A., Costa, S. K. P., Ferreira, A. F. F., Britto, L. R., De Camargo, J. A., Rodrigues De Oliveira, D., De Jesus, F. N., Otoch, J. P., & Pessoa, A. F. M. (2022). The symbiotic effect of a new nutraceutical with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) for recovering metabolic homeostasis via Pgc-1α, Il-6, and Il-10 gene expression in a type-2 diabetes obesity model. Antioxidants, 11(3), 447. https://doi.org/10.3390/antiox11030447
- Sarima, P., Pistanty, M. A., Fathia, M., & Winanda, W. (2025). The potential of various matoa plant (Pometia pinnata) extracts as antibacterial agents: Systematic literature review. Nutritional Research Review, 11, 1–10.
- World Obesity Federation. (2025). World obesity atlas 2025. https://s3-eu-west-1.amazonaws.com/wof-files/World_Obesity_Atlas_2025_rev1.pdf
- Zhang, C., Zhang, Q., Zhang, X., Du, S., Zhang, Y., Wang, X., Liu, Y., Fang, B., Chen, J., Liu, R., Hao, Y., Li, Y., Wang, P., Zhao, L., Feng, H., Zhu, L., Chen, L., Chen, S., Wang, F., … He, J. (2025). Effects of synbiotics surpass probiotics alone in improving type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 44, 248–258. https://doi.org/10.1016/j.clnu.2024.11.042
- Zhu, Q., Azad, M. A. K., Li, R., Li, C., Liu, Y., Yin, Y., & Kong, X. (2024). Dietary probiotic and synbiotic supplementation starting from maternal gestation improves muscular lipid metabolism in offspring piglets by reshaping colonic microbiota and metabolites. mSystems, 9(6), e00048-24. https://doi.org/10.1128/msystems.00048-24
Copyright (c) 2026 Miftahul Jannah, Prananingrum Kinasih, Dhiya Fadhila Rahmah

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.