Perbaikan kadar trigliserida dan Hs-CRP pada tikus Wistar Diabetes Mellitus tipe 2 dengan biskuit biji bunga matahari

Efina Amanda -  Departemen Ilmu Gizi, Universitas Diponegoro, Semarang, Indonesia
Achmad Zulfa Juniarto -  Fakultas Kedokteran, Universitas Diponegoro, Semarang, Indonesia
Diana Nur Afifah* -  Departemen Ilmu Gizi, Universitas Diponegoro, Semarang, Indonesia
Muflihatul Muniroh -  Fakultas Kedokteran, Universitas Diponegoro, Semarang, Indonesia
Ahmad Ni'matullah Al-Baarri -  Program Studi Teknologi Pangan, Universitas Diponegoro, Indonesia
Deny Yudi Fitranti -  Departemen Ilmu Gizi, Universitas Diponegoro, Semarang, Indonesia
DOI : 10.30867/action.v6i2.560

Supp. File(s): Research Instrument
Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion or insulin action. Increased glucose allows free fatty acids to enter as raw material for forming triglycerides. Hs-CRP can be used to identify the most sensitive inflammatory markers in diabetes. This study aims to analyze the effect of sunflower seed biscuits on triglyceride levels and Hs-CRP in Wistar rats with type 2 diabetes mellitus. The method is a true experiment with a randomized pre-post test with a control group design. The research sample size was 24 male Wistar rats, divided into four control groups K(-), K(+), and treatment P1, P2. The intervention was carried out for 28 days, and triglycerides were measured by spectrophotometer, and Hs-CRP was measured using the ELISA method. Statistical analysis used three tests, namely the Paired T-Test, the Kruskal Wallis test, and the Spearman correlation test. There are differences after the intervention and changes between groups with triglyceride values before intervention 145 mg/dl and after intervention 145 mg/dl and Hs-CRP values before intervention 14.8 mg/l and after intervention 14,8 mg/l. Changes between groups of triglyceride and Hs-CRP levels after statistical tests (p= 0,000) and (p= 0,000), respectively. The conclusion is a provision of sunflower seed biscuits showed an effect on triglyceride and Hs-CRP levels of type 2 diabetes mellitus rats. The lowest decrease in triglyceride and Hs-CRP levels was found in the treated rats with a dose of 1440 mg / 200 g of rats

Supplement Files

Keywords : Hs-CRP, sunflower seed biscuits, type 2 diabetes mellitus, triglyceride

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Open Access Copyright (c) 2021 Efina Amanda, Achmad Zulfa Juniarto, Diana Nur Afifah, Muflihatul Muniroh, Ahmad Ni'matullah Al-Baarri, Deny Yudi Fitranti
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AcTion: Aceh Nutrition Journal
Published by: Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health.
Soekarno-Hatta Street, No. 168. Health Polytechnic of Aceh, Aceh Besar, 23352. Telp/Fax: 0651 46126 / 0651 46121.
Website: https://gizipoltekkesaceh.ac.id/
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