Literatur Review: Pembatasan energi untuk peningkatan umur panjang. Manajemen alternatif terhadap metabolik obesitas

Sophia Rose -  Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Indonesia
Etika Ratna Noer* -  Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Indonesia
Muflihatul Muniroh -  Departemen Ilmu Fisiologi, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Indonesia
Apoina Kartini -  Departemen Gizi Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Diponegoro, Semarang, Indonesia

Supp. File(s): Research Instrument Copyright Agreement Etika Publikasi

Diet development today tends to lead to accelerated growth of chronic diseases. Obesity plays a negative role in the development of chronic disease. This risk factor also occurs in the aging process. The condition of organ tissue dysfunction and cell death that occurs with aging also occurs in obesity due to chronic inflammation. This study analyzes the beneficial effects of applying Calorie Restriction (CR) or Energy Restriction (PE) to achieve a long life span, especially in obese individuals. This article is a literature review study with qualitative analysis by searching the PubMed electronic database from February to July 2021 and searching for articles through Meta-analysis, Review, and Systematic Review. Six articles have high relevance. References obtained were compiled and reviewed by summarizing and analyzed by triangulation. Furthermore, examining previous research's pros and cons finally gives alternative solutions. The results of the study showed the application of the PE method by reducing daily energy consumption without causing the risk of malnutrition because it still considers an essential nutrient. In conclusion, the benefits of PE have an impact on slowing down aging molecularly. Slowing down the aging process can increase a person's life expectancy.

Supplement Files

Keywords : Aging, Calorie restriction, Obesity

  1. Austad, S. N., & Hoffman, J. M. (2021). Beyond calorie restriction: aging as a biological target for nutrient therapies. Current Opinion in Biotechnology, 70, 56–60.
  2. Badan Penelitian dan Pengembangan Kesehatan Kemenkes RI. (2018). Hasil Utama Riskesdas 2018.
  3. D’Amico, A. M., & Vasquez, K. M. (2021). The multifaceted roles of DNA repair and replication proteins in aging and obesity. DNA Repair, 99, 103049.
  4. Das, M., Sauceda, C., & Webster, Ni. J. (2021). Mitochondrial Dysfunction in Obesity and Reproduction. Endocrinology, 162(1), 1–13.
  5. Dias, I. R., Santos, C. de S., Magalhães, C. O. D. e., de Oliveira, L. R. S., Peixoto, M. F. D., De Sousa, R. A. L., & Cassilhas, R. C. (2020). Does calorie restriction improve cognition? IBRO Reports, 9, 37–45.
  6. Dorling, J. L., Bhapkar, M., Das, S. K., Racette, S. B., Apolzan, J. W., Fearnbach, S. N., Redman, L. M., Myers, C. A., Stewart, T. M., & Martin, C. K. (2019). Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity. Appetite, 143, 104397.
  7. Dorling, J., Martin, C., & Redman, L. (2020). Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment. Ageing Research Reviews, 64, 101038.
  8. Dwivedi, A. K., Dubey, P., Cistola, D. P., & Reddy, S. Y. (2020). Association between obesity and cardiovascular outcomes: Updated evidence from meta-analysis studies. Current Cardiology Reports, 22(4), 1–14.
  9. Ferretti, F., & Mariani, M. (2017). Simple vs. complex carbohydrate dietary patterns and the global overweight and obesity pandemic. International Journal of Environmental Research and Public Health, 14(10), 1–12.
  10. Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020). Calorie restriction and aging in humans. Annual Review of Nutrition, 40(9), 105–133.
  11. Formica, V., Morelli, C., Riondino, S., Renzi, N., Nitti, D., Di Daniele, N., Roselli, M., & Tesauro, M. (2020). Obesity and common pathways of cancer and cardiovascular disease. Endocrine and Metabolic Science, 1(3–4), 100065.
  12. Gabandé-Rodríguez, E., Mittelbrunn, M., & de las Heras, M. M. G. (2020). Control of inflammation by calorie restriction mimetics: On the crossroad of autophagy and mitochondria. Cells, 9(1), 1–22.
  13. Golbidi, S., Daiber, A., Korac, B., Li, H., Essop, M. F., & Laher, I. (2017). Health benefits of fasting and caloric restriction. Current Diabetes Reports, 17(123), 1–11.
  14. Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020). The road ahead for health and lifespan interventions. Ageing Research Reviews, 59, 101037.
  15. Hannan, M. A., Rahman, M. A., Rahman, M. S., Sohag, A. A. M., Dash, R., Hossain, K. S., Farjana, M., & Uddin, M. J. (2020). Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response. Immunology Letters, 226, 38–45.
  16. Heinonen, S., Buzkova, J., Muniandy, M., Kaksonen, R., Ollikainen, M., Ismail, K., Hakkarainen, A., Lundbom, J., Lundbom, N., Vuolteenaho, K., Moilanen, E., Kaprio, J., Rissanen, A., Suomalainen, A., & Pietiläinen, K. H. (2015). Impaired mitochondrial biogenesis in adipose tissue in acquired obesity. Diabetes, 64(9), 3135–3145.
  17. Heinonen, S., Jokinen, R., Rissanen, A., & Pietiläinen, K. H. (2020). White adipose tissue mitochondrial metabolism in health and in obesity. Obesity Reviews, 21(2), e12958.
  18. Hooper, L., Bunn, D., Jimoh, F. O., & Fairweather-Tait, S. J. (2014). Water-loss dehydration and aging. Mechanisms of Ageing and Development, 136–137, 50–58.
  19. Hussin, N. M., Shahar, S., Teng, N. I. M. F., Ngah, W. Z. W., & Das, S. K. (2013). Efficacy of Fasting and Calorie Restriction (FCR) on mood and depression among ageing men. Journal of Nutrition, Health and Aging, 17(8), 674–680.
  20. Keleszade, E., Willner, T., Patterson, M., Trangmar, S., Kolida, S., & Costabile, A. (2020). A pilot study to assess the effect of a fibre and mineral formulation on satiety and satiation when taken as part of a calorie restriction diet in overweight and obese women. Journal of Functional Foods, 74, 104157.
  21. Klempel, M. C., Kroeger, C. M., Bhutani, S., Trepanowski, J. F., & Varady, K. A. (2012). Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal, 11(98), 1–9.
  22. Korolchuk, V. I., Miwa, S., Carroll, B., & von Zglinicki, T. (2017). Mitochondria in cell senescence: is mitophagy the weakest link? EBioMedicine, 21, 7–13.
  23. Kraus, W. E., Bhapkar, M., Huffman, K. M., Pieper, C. F., Das, S. K., Redman, L. M., Villareal, D. T., Rochon, J., Roberts, S. B., Ravussin, E., Holloszy, J. O., & Fontana, L. (2019). 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinol, 7(9), 673–683.
  24. Lee, J. H., Park, A., Oh, K. J., Lee, S. C., Kim, W. K., & Bae, K. H. (2019). The role of adipose tissue mitochondria: Regulation of mitochondrial function for the treatment of metabolic diseases. International Journal of Molecular Sciences, 20(19), 1–22.
  25. Lefranc, C., Persson, M. F., Ramirez, R. P., & et al. (2018). Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor. Journal of Endocrinology, 238(3), 143–159.
  26. Liu, D., Huang, Y., Huang, C., Yang, S., Wei, X., Zhang, P., Guo, D., Lin, J., Xu, B., Li, C., He, H., He, J., Liu, S., Shi, L., Xue, Y., & Zhang, H. (2022). Calorie restriction with or without time-restricted eating in weight loss. New England Journal of Medicine, 386(16), 1495–1504.
  27. Lluch, G. L., & Navas, P. (2016). Calorie restriction as an intervention in ageing. The Journal of Physiology, 594(8), 2043–2060.
  28. Manuel-y-Keenoy, B. (2012). Metabolic impact of the amount and type of dietary carbohydrates on the risk of obesity and diabetes. The Open Nutrition Journal, 6(1), 21–34.
  29. Mehrabani, S., Bagherniya, M., Askari, G., Read, M. I., & Sahebkar, A. (2020). The effect of fasting or calorie restriction on mitophagy induction: a literature review. Journal of Cachexia, Sarcopenia and Muscle, 11(6), 1447–1458.
  30. Montgomery, M. K. (2019). Mitochondrial dysfunction and diabetes: Is mitochondrial transfer a friend or foe? Biology, 8(2), 33.
  31. Parkhitko, A. A., Filine, E., Mohr, S. E., Moskalev, A., & Perrimon, N. (2020). Targeting metabolic pathways for extension of lifespan and healthspan across multiple species. Ageing Research Reviews, 64, 101188.
  32. Parvaresh, A., Razavi, R., Abbasi, B., Yaghoobloo, K., Hassanzadeh, A., Mohammadifard, N., Safavi, S. M., Hadi, A., & Clark, C. C. T. (2019). Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial. Complementary Therapies in Medicine, 47, 102187.
  33. Popkin, B. M., D’Anci, K. E., & Rosenberg, I. H. (2010). Water, hydration, and health. Nutrition Reviews, 68(8), 439–458.
  34. Prehn, K., von Schwartzenberg, R. J., Mai, K., Zeitz, U., Witte, A. V., Hampel, D., Szela, A. M., Fabian, S., Grittner, U., Spranger, J., & Flöel, A. (2017). Caloric restriction in older adults-differential effects of weight loss and reduced weight on brain structure and function. Cerebral Cortex, 27(3), 1765–1778.
  35. Santos, A. L., & Sinha, S. (2021). Obesity and aging: Molecular mechanisms and therapeutic approaches. Ageing Research Reviews, 67, 101268.
  36. Schols, J. M. G. A., de Groot, C. P. G. M., van der Cammen, T. J. M., & Olde Rikkert, M. G. M. (2009). Preventing and treating dehydration in the elderly during periods of illness and warm weather. Journal of Nutrition, Health and Aging, 13(2), 150–157.
  37. So, R., & Matsuo, T. (2020). Effects of using high-intensity interval training and calorie restriction in different orders on metabolic syndrome: A randomized controlled trial. Nutrition, 75, 110666.
  38. Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., Schroeder, S., Tadic, J., Eisenberg, T., Magnes, C., Stumpe, M., Zuegner, E., Bordag, N., Riedl, R., Schmidt, A., … Madeo, F. (2019). Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans. Cell Metabolism, 30(3), 462-476.e5.
  39. Thornton, S. N. (2016). Increased hydration can be associated with weight loss. Frontiers in Nutrition, 3(18), 1–8.
  40. Trepanowski, J. F., Kroeger, C. M., Barnosky, A., Klempel, M., Bhutani, S., Hoddy, K. K., Rood, J., Ravussin, E., & Varady, K. A. (2018). Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clinical Nutrition, 37(6), 1871–1878.
  41. Welton, S., Minty, R., O’Driscoll, T., Willms, H., Poirier, D., Madden, S., & Kelly, L. (2020). Intermittent fasting and weight loss: Systematic review. Canadian Family Physician, 66(2), 117–125.
  42. WHO. (2012). Obesity: bad trouble is on its way. World Health Organization (WHO).
  43. WHO. (2021). Obesity. World Health Organization (WHO).
  44. Wongchum, N., & Dechakhamphu, A. (2021). Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 244, 108994.
  45. Zhu, S., Tian, Z., Torigoe, D., Zhao, J., Xie, P., Sugizaki, T., Sato, M., Horiguchi, H., Terada, K., Kadomatsu, T., Miyata, K., & Oike, Y. (2019). Aging- And obesity-related peri-muscular adipose tissue accelerates muscle atrophy. PLoS ONE, 14(8), 1–18.

Open Access Copyright (c) 2023 Sophia Rose, Etika Ratna Noer, Muflihatul Muniroh3 Apoina Kartini
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

AcTion: Aceh Nutrition Journal
Published by: Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health.
Soekarno-Hatta Street, No. 168. Health Polytechnic of Aceh, Aceh Besar, 23352. Telp/Fax: 0651 46126 / 0651 46121.

e-issn: 2548-5741, p-issn: 2527-3310

All content is licensed under a: Creative Commons Attribution ShareAlike 4.0 International License

View My Stats

Get a feed by atom here, RRS2 here and OAI Links here