Gambaran nilai laktat, ScvO2, dan PvaCO2 GAP pada pasien sepsis di Rumah Sakit Umum Haji Adam Malik Medan
DOI: 10.30867/gikes.v5i3B.1946Abstract
Background: We need a prognostic predictive value in sepsis and septic shock patients to determine the aggressiveness of the therapy we will choose. We use various methods to predict patient mortality. To assess tissue perfusion disorders, we need markers. Lactate, SvO2, and PvaCO2 gaps are commonly used as early biomarkers to assess tissue perfusion and cellular oxygenation.
Objectives: To describe the value of lactate, ScvO2, and PvaCO2 gap in septic patients.
Methods: This study is an analytical descriptive study that examines the lactate value, ScvO2, and PvaCO2 gap in 40 patients diagnosed with sepsis. We conducted the study in the emergency room (IGD) of the Hajj Adam Malik Hospital in MedanWe began by gathering information from research samples that satisfied the inclusion and exclusion criteria, providing explanations to the families of patients involved in the study, obtaining blood samples, and conducting data analysis. We used ultranonography to collect blood from the central vein. The SPSS application carried out data analysis using univariate tests.
Results: In this study, the lactate values were found in the normal range with an average of 1.45 ± 1.81, the ScvO2 value increased by an average of 91.29 ± 7.91, and the PvaCO2 gap value increased by an average of 11.52 ± 8.28.
Conclusion: In this study, lactate values were above normal, with AGDA parameters indicating metabolic acidosis expression. ScvO2 PvaCO2 gap value that increased.
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Barichello, T., Generoso, J. S., Singer, M., & Dal-Pizzol, F. (2022). Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review. Critical Care, 26(1), 1–31. https://doi.org/10.1186/S13054-021-03862-5/FIGURES/1
Bisarya, R., Shaath, D., Pirzad, A., Satterwhite, L., He, J., & Simpson, S. Q. (2019). Serum lactate poorly predicts central venous oxygen saturation in critically ill patients: a retrospective cohort study. Journal of Intensive Care, 7(1). https://doi.org/10.1186/S40560-019-0401-5
Bone, R. C. (1997). Sepsis: A New Hypothesis for Pathogenesis of the Disease Process. CHEST Journal, 112(1), 235. https://doi.org/10.1378/chest.112.1.235
Bou Chebl, R., Jamali, S., Sabra, M., Safa, R., Berbari, I., Shami, A., Makki, M., Tamim, H., & Abou Dagher, G. (2020). Lactate/Albumin Ratio as a Predictor of In-Hospital Mortality in Septic Patients Presenting to the Emergency Department. Frontiers in Medicine, 7. https://doi.org/10.3389/FMED.2020.550182
Cao, C., Yu, M., & Chai, Y. (2019). Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis. Cell Death & Disease, 10(10). https://doi.org/10.1038/S41419-019-2015-1
Chancharoenthana, W., Leelahavanichkul, A., & Eiam-Ong, S. (2017). Sepsis-associated Acute Kidney Injury. In Sepsis. InTech. https://doi.org/10.5772/intechopen.69612
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., MacHado, F. R., McIntyre, L., Ostermann, M., Prescott, H. C., Schorr, C., Simpson, S., Wiersinga, W. J., Alshamsi, F., Angus, D. C., Arabi, Y., Azevedo, L., Beale, R., Beilman, G., … Levy, M. (2021). Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine, 49(11), E1063–E1143. https://doi.org/10.1097/CCM.0000000000005337
Guirgis, F. W., Khadpe, J. D., Kuntz, G. M., Wears, R. L., Kalynych, C. J., & Jones, A. E. (2014). Persistent organ dysfunction after severe sepsis: A systematic review. Journal of Critical Care, 29(3), 320–326. https://doi.org/10.1016/j.jcrc.2013.10.020
Gyawali, B., Ramakrishna, K., & Dhamoon, A. S. (2019). Sepsis: The evolution in definition, pathophysiology, and management. SAGE Open Medicine, 7. https://doi.org/10.1177/2050312119835043
Hamonangan Nasution, A., & Stya Yulianda, R. (2020). The Effect of Thiamine Administration on Interleukin-6 (Il-6) Enzyem, Lactate and Sequential Organ Failure Assessment (SOFA) Score in Patients with Sepsis. Ashdin Publishing Journal of Drug and Alcohol Research, 9. https://doi.org/10.4303/jdar/236093
Hotchkiss, R. S., & Karl, I. E. (2003). The pathophysiology and treatment of sepsis. The New England Journal of Medicine, 348(2), 138–150. https://doi.org/10.1056/NEJMra021333
Kurniawan, M. B., Pradian, E., & Nawawi, A. M. (2017). Lactate Clearance sebagai Prediktor Mortalitas pada Pasien Sepsis Berat dan Syok Septik di Intesive Care Unit Rumah Sakit Dr. Hasan Sadikin Bandung. Jurnal Anestesi Perioperatif, 5(1), 45–50. https://doi.org/10.15851/JAP.V5N1.1003
Ospina-Tascón, G. A., Umaña, M., Bermúdez, W., Bautista-Rincón, D. F., Hernandez, G., Bruhn, A., Granados, M., Salazar, B., Arango-Dávila, C., & De Backer, D. (2015). Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock. Intensive Care Medicine, 41(5), 796–805. https://doi.org/10.1007/s00134-015-3720-6
Pant, A., Mackraj, I., & Govender, T. (2021). Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology. Journal of Biomedical Science 2021 28:1, 28(1), 1–30. https://doi.org/10.1186/S12929-020-00702-6
Pierrakos, C., de Bels, D., Nguyen, T., Velissaris, D., Attou, R., Devriendt, J., Honore, P. M., Taccone, F. S., & de Backer, D. (2021). Changes in central venous-to-arterial carbon dioxide tension induced by fluid bolus in critically ill patients. PLOS ONE, 16(9), e0257314. https://doi.org/10.1371/JOURNAL.PONE.0257314
Rivers, E. P., Yataco, A. C., Jaehne, A. K., Gill, J., & Disselkamp, M. (2015). Oxygen extraction and perfusion markers in severe sepsis and septic shock: diagnostic, therapeutic and outcome implications. Current Opinion in Critical Care, 21(5), 381–387. https://doi.org/10.1097/MCC.0000000000000241
Semeraro, N., Ammollo, C., Semeraro, F., & Colucci, M. (2010). Sepsis-associated disseminated intravascular coagulation and thromboembolic disease. Mediterr J Hematol Infect Dis, 2(3), 20–24.
Septimus, E. J. (2020). Sepsis Perspective 2020. The Journal of Infectious Diseases, 222(Suppl 2), S71–S73. https://doi.org/10.1093/INFDIS/JIAA220
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., Hotchkiss, R. S., Levy, M. M., Marshall, J. C., Martin, G. S., Opal, S. M., Rubenfeld, G. D., van der Poll, T., Vincent, J.-L., & Angus, D. C. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8), 801–810. https://doi.org/10.1001/jama.2016.0287
Sitthikool, K., Boyd, J. H., Russell, J. A., & Walley, K. R. (2021). Value of combined lactate and central venous oxygen saturation measurement in patients with sepsis: a retrospective cohort study. Annals of Critical Care, 2021(4), 59–68. https://doi.org/10.21320/1818-474X-2021-4-59-68
Spapen, H., Jacobs, R., & Honoré, P. (2017). Sepsis-induced multi-organ dysfunction syndrome—a mechanistic approach. J Emerg Crit Care Med, 1(10), 27.
Sudhir, U., Venkatachalaiah, R. K., Kumar, T. A., Rao, M. Y., & Kempegowda, P. (2011). Significance of serum procalcitonin in sepsis. Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine, 15(1), 1–5. https://doi.org/10.4103/0972-5229.78214
Valeanu, L., Bubenek‐turconi, S. I., Ginghina, C., & Balan, C. (2021). Hemodynamic Monitoring in Sepsis-A Conceptual Framework of Macro- and Microcirculatory Alterations. Diagnostics (Basel, Switzerland), 11(9). https://doi.org/10.3390/DIAGNOSTICS11091559
Wittayachamnankul, B., Apaijai, N., Sutham, K., Chenthanakij, B., Liwsrisakun, C., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2020). High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study. Journal of Cellular and Molecular Medicine, 24(11), 6485–6494. https://doi.org/10.1111/JCMM.15299
Woyka, S., Purwoko, & Ardana. (2021). Korelasi Kadar ScVO2 dengan Skor Sequential Organ Failure Assesment (SOFA) pada Pasien Sepsis di Intensive Care Unit (ICU) RSUD Dr. Moewardi Surakarta. Majalah Anestesia & Critical Care, 39(3), 152–158. https://doi.org/10.55497/MAJANESTCRICAR.V39I3.230
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