Pengaruh pemberian obat anti tuberkulosis dengan vitamin D terhadap perubahan BTA pada penderita tuberkulosis paru di Kabupaten Pidie

Author(s): Rina Maulidar, Nurjannah Nurjannah, Aulina Adamy, Iskandar Iskandar
DOI: 10.30867/gikes.v2i1.442

Abstract

Background: Tuberculosis (TB) is a global health problem, Indonesia had the second rank of the case in the world after India which is the fourth cause of death. Giving vitamin D together with anti-tuberculosis drugs can increase healing proses because vitamin D (anti-microbial immunomodulators) kills Mycobacterium tuberculosis.

Objectives: This study aims to measure the effect of giving anti-tuberculosis drugs with vitamin D on changes in AFB in patients with pulmonary tuberculosis.

Methods: This study was used a quasi-experiment design, pre-test and post-test control group was doing at 25th March – 25th July 2019. This research has been conducted in Pidie Regency. The intervention group (17 samples with tuberculosis drugs) was given Softgels vitamin D 5000 IU for 4 months, while the control group was only anti-tuberculosis drug therapy. The data were analyzed statistically using the Wilcoxon and Mann Whitney tests at a significance level of 95%.

Results: Before the intervention, the BTA status of both the intervention and control group was similar (p= 0.061). After the intervention, there was a decrease in AFB interactions (p= 0.000). There was a decrease in the contribution of AFB in the control group before with after intervention (p= 0.000). There are those who support (p= 0.033) giving vitamin D the acceleration of pulmonary tuberculosis treatment.

Conclusion: It is better to administer vitamin D to the successful treatment of pulmonary TB in patients undergoing anti-tuberculosis drug therapy.

Keywords

Pulmonary TB; tuberculosis drugs; vitamin D

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References

Balitbangkes. (2013). Laporan riskesdas 2013. In Jakarta: Badan Penelitian dan Pengembangan Kesehatan.

Balitbangkes. (2018). Laporan Riset Kesehatan Dasar Tahun 2018.

Dinkes Kabupaten Pidie. (2018). Profil Kesehatan Kabupaten Pidie.

Gibney, K. B., MacGregor, L., Leder, K., Torresi, J., Marshall, C., Ebeling, P. R., & Biggs, B.-A. (2008). Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clinical Infectious Diseases, 46(3), 443–446.

Glaziou, P., Sismanidis, C., Floyd, K., & Raviglione, M. (2015). Global epidemiology of tuberculosis. Cold Spring Harbor Perspectives in Medicine, 5(2), a017798.

Gustina, F. (2006). Aplikasi Uji Khi-Kuadrat Mantel Haenszel Dan Uji Regresi Logistik Ganda Untuk Penilaian Peranan Variabel Perancu Pada Hubungan Antara Peritas Dengan Partus Prematur (Studi di RSU Dr. Soetomo Surabaya). Universitas Airlangga.

Holick, M., Nutrition, T. C.-T. A. journal of clinical, & 2008, U. (2008). Vitamin D deficiency: a worldwide problem with health consequences. The American Journal of Clinical Nutrition, 87(4), 1080S-1086S. https://academic.oup.com/ajcn/article-abstract/87/4/1080S/4633477

Indriati, G. (2015). Faktor-faktor yang mempengaruhi keberhasilan pengobatan tuberkulosis paru. Jurnal Online Mahasiswa Program Studi Ilmu Keperawatan Universitas Riau, 2(1), 729–741.

Ji, W., Malong, F., Shidong, Y., Jianfang, Z., & Xiaoqing, L. I. (2018). Efficacy and safety of vitamin D supplementation for pulmonary tuberculosis: a systematic review and meta-analysis. Iranian Journal of Public Health, 47(4), 466.

Kemenkes RI. (2016). Pencegahan dan Pengendalian Penyakit, Data dan Informasi Kesehatan.

Linder, M. C. (1992). Biokimia nutrisi dan metabolisme dengan pemakaian secara Klinis. Cetakan Pertama. Penerbit Universitas Indonesia, Jakarta.

Martineau, A. R., Timms, P. M., Bothamley, G. H., Hanifa, Y., Islam, K., Claxton, A. P., Packe, G. E., Moore-Gillon, J. C., Darmalingam, M., & Davidson, R. N. (2011). High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. The Lancet, 377(9761), 242–250.

Nursyam, E. W., Amin, Z., & Rumende, C. M. (2006). The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Hemoglobin, 1500, 1500.

Pratomo, I. P., Burhan, E., & Tambunan, V. (2012). Malnutrisi dan tuberkulosis. J Indon Med Assoc, 62(230), 7–12.

Ramdan, A., Ismiarto, Y. D., KR, F. Y., & Albana, R. (2018). Kadar Vitamin D [25 (OH) D] Serum Pasien Tuberkulosis Tulang Belakang dan Tuberkulosis Paru di Bandung, Indonesia: Studi Epidemiologi. Cermin Dunia Kedokteran, 45(6), 414–417.

Salahuddin, N., Ali, F., Hasan, Z., Rao, N., Aqeel, M., & Mahmood, F. (2013). Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonar. BMC Infectious Diseases, 13(1), 1–11.

Setiabudiawan, B., Kartasasmita, C. B., Garna, H., Parwati, I., & Maskoen, A. M. (2010). Polimorfisme FokI, BsmI, ApaI, dan TaqI gen reseptor vitamin D pada kejadian tuberkulosis anak. Majalah Kedokteran Bandung, 42(4), 187–194.

Soepandi, P. Z. (2010). Diagnosis dan faktor yang mempengaruhi terjadinya TB-MDR. Jurnal Tuberkulosis Indonesia, 7(2), 16–19.

Sugiarti, S., Ramadhian, M. R., & Carolia, N. (2018). Vitamin D sebagai Suplemen dalam Terapi Tuberkulosis Paru. Jurnal Majority, 7(2), 198–202.

Syafei, Z., Suryani, S. W., & Rifsal, D. S. (2018). Hubungan kadar vitamin D plasma dengan IMT dan umur pada kanker payudara. AcTion: Aceh Nutrition Journal, 3(2), 117–123.

Talat, N., Perry, S., Parsonnet, J., Dawood, G., & Hussain, R. (2010). Vitamin D deficiency and tuberculosis progression. Emerging Infectious Diseases, 16(5), 853.

Thuraidah, A., Astuti, R. A. W., & Rakhmina, D. (2017). Anemia dan Lama Konsumsi Obat Anti Tuberculosis. Medical Laboratory Technology Journal, 3(2), 42–46.

Tukvadze, N., Sanikidze, E., Kipiani, M., Hebbar, G., Easley, K. A., Shenvi, N., Kempker, R. R., Frediani, J. K., Mirtskhulava, V., & Alvarez, J. A. (2015). High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial. The American Journal of Clinical Nutrition, 102(5), 1059–1069.

Wejse, C., Gomes, V. F., Rabna, P., Gustafson, P., Aaby, P., Lisse, I. M., Andersen, P. L., Glerup, H., & Sodemann, M. (2009). Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. American Journal of Respiratory and Critical Care Medicine, 179(9), 843–850.

DOI: http://dx.doi.org/10.30867/gikes.v2i1.442

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