Efektivitas kombinasi pembatasan kalori dan kapsul kacang kedelai (Glycine max) terhadap kadar trigliserida pada individu obesitas usia 25-45 tahun

Author(s): Hanifah Mardhotillah, Al Rivan Marsyah Dzikri, Fitriani Ekawati
DOI: 10.30867/gikes.v7i1.3083

Abstract

Background: Obesity is significantly associated with lipid metabolism disorders, one of which is characterized by elevated triglyceride levels that may lead to cardiovascular complications. Caloric restriction is a commonly applied non-pharmacological approach for managing obesity; however, its effectiveness may be enhanced when combined with functional foods, such as soybeans, which are rich in bioactive compounds.

Objectives: This study aimed to evaluate the effects of caloric restriction combined with soybean capsule consumption on triglyceride levels in individuals with obesity.

Methods: This study was conducted in Kuningan, West Java, using a single-blind randomized controlled trial with a pre-post design over 14-day period. Thirty individuals with obesity were randomly assigned to two groups. The control group underwent caloric restriction of 1800 kcal/day, whereas the intervention group received the same caloric restriction along with 3000 mg/day soybean capsules. Triglyceride levels were measured before and after the intervention. Data were analyzed using parametric and non-parametric tests according to the data distribution, with a 95% confidence interval (CI), complemented by effect size analysis using Cohen’s d.

Results: The intervention group demonstrated a significantly greater reduction in triglyceride levels than that in the control group (p = 0.004). The mean decrease in triglyceride levels was 5.9±3.9 mg/dL in the intervention group, whereas the control group showed a reduction of 3.13±1.64 mg/dL. Cohen’s d value of 0.93 indicated a large effect size.

Conclusion: The combination of caloric restriction and soybean capsules for 14 days resulted in a more significant reduction in triglyceride levels than caloric restriction alone. These findings suggest a potential short-term metabolic benefit in individuals with obesity.

Keywords

Soybeans, obesity, functional foods, calorie restriction, triglycerides

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References

Al Hashmi, K., Giglio, R. V., Pantea Stoian, A., Patti, A. M., Al Waili, K., Al Rasadi, K., Ciaccio, M., & Rizzo, M. (2024). Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies. Frontiers in Nutrition, 11(March), 1–9. https://doi.org/10.3389/fnut.2024.1355732

Ansyah, R. A. (2023). Study Literatur: Kacang Kedelai sebagai Obat Herbal Indonesia Penurun Kadar Kolesterol. Herbal Medicine Journal, 6(2), 19–25. https://doi.org/10.58996/hmj.v6i1.83

Barańska, A., Błaszczuk, A., Kanadys, W., Baczewska, B., Jędrych, M., Wawryk-Gawda, E., & Polz-Dacewicz, M. (2021). Effects of soy protein containing of isoflavones and isoflavones extract on plasma lipid profile in postmenopausal women as a potential prevention factor in cardiovascular diseases: Systematic review and meta-analysis of randomized controlled trials. Nutrients, 13(8). https://doi.org/10.3390/nu13082531

Betaditya, D., Ramadhan, G. R., Subardjo, Y. P., Betari, F., & Yustika, I. B. (2022). Kandungan Gula dan Konsumsi Minuman “Franchise” sebagai Faktor Risiko Overweight. Jurnal Ilmiah Kesehatan (JIKA), 4(2), 193–201. http://salnesia.id/index.php/jika

Cao, Y. (2025). The protective effects of soy isoflavones on the cardiovascular system. 428–432. https://doi.org/10.1145/3745034.3745100

do Prado, F. G., Pagnoncelli, M. G. B., de Melo Pereira, G. V., Karp, S. G., & Soccol, C. R. (2022). Fermented Soy Products and Their Potential Health Benefits: A Review. Microorganisms, 10(8), 1–24. https://doi.org/10.3390/microorganisms10081606

Dom, S., & Carrillo-fern, L. (2020). Waist Circumference and Blood Glucose Obesity . The DISFRUTE Study : A Randomised Trial. Nutrients, 12(4), 1–19.

Dorling, J. L., Van Vliet, S., Huffman, K. M., Kraus, W. E., Bhapkar, M., Pieper, C. F., Stewart, T., Das, S. K., Racette, S. B., Roberts, S. B., Ravussin, E., Redman, L. M., & Martin, C. K. (2021). Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: Highlights from CALERIE phase 2. Nutrition Reviews, 79(1), 98–113. https://doi.org/10.1093/nutrit/nuaa085

Downstream, I., Akt, S., & Cells, H. (2021). Genistein Regulates Lipid Metabolism via Estrogen Receptor β. Nutrients, 13, 4015.

Hakkak, R., Korourian, S., Li, W., Spray, B., Twaddle, N. C., Randolph, C. E., Børsheim, E., & Robeson, M. S. (2024). Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level. Frontiers in Nutrition, 11(October), 1–13. https://doi.org/10.3389/fnut.2024.1487859

Harianto, I., Aprilia, D., Ruhiya, F., & Rohmayanti, T. (2025). Peran Senyawa Bioaktif Kedelai dalam Pangan Fungsional dan Kesehatan. Karimah Tauhid, 4(6), 3403–3413. https://doi.org/10.30997/karimahtauhid.v4i6.17968

Hatami Zargaran, Z., Salehi, M., Taghi Heydari, S., & Babajafari, S. (2014). The effects of 6 Isocaloric Meals on Body Weight, Lipid Profiles, Leptin, and Adiponectin in Overweight Subjects (BMI > 25). International Cardiovascular Research Journal, 8(2), 52–56.

Hu, S., Liu, C., & Liu, X. (2023). The Beneficial Effects of Soybean Proteins and Peptides on Chronic Diseases. Nutrients, 15(8), 1–18. https://doi.org/10.3390/nu15081811

Huffman, K. M., Parker, D. C., Bhapkar, M., Racette, S. B., Martin, C. K., Redman, L. M., Das, S. K., Connelly, M. A., Pieper, C. F., Orenduff, M., Ross, L. M., Ramaker, M. E., Dorling, J. L., Rosen, C. J., Shalaurova, I., Otvos, J. D., Kraus, V. B., & Kraus, W. E. (2022). Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIETM a multicentre, phase 2, randomised controlled trial. EClinicalMedicine, 43, 101261. https://doi.org/10.1016/j.eclinm.2021.101261

Kim, J. Y. (2021). Optimal diet strategies for weight loss and weight loss maintenance. Journal of Obesity and Metabolic Syndrome, 30(1), 20–31. https://doi.org/10.7570/JOMES20065

Lee, H. Y., & Min, K. J. (2024). Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan. Nutrients , 16(24). https://doi.org/10.3390/nu16244424

Ligia, E. D., Sonia, G., Vicente-castro, I., Heredia, C., & Nova, E. (2022). Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes. Nutriens, 14(1937), 1–17.

Liu, D., Huang, Y., Huang, C., Yang, S., Wei, X., Zhang, P., Guo, D., Lin, J., Xu, B., Li, C., He, H., He, J., Liu, S., Shi, L., Xue, Y., & Zhang, H. (2022). Calorie Restriction with or without Time-Restricted Eating in Weight Loss. New England Journal of Medicine, 386(16), 1495–1504. https://doi.org/10.1056/nejmoa2114833

Mardhotillah, H., Afifah, D. N., & Pramono, A. (2024). Hanifah Mardhotillah 1 , Diana Nur Afifah 2* , Adriyan Pramono 3.

Most, J., & Redman, L. M. (2020). Impact of calorie restriction on energy metabolism in humans. Experimental Gerontology, 133. https://doi.org/10.1016/j.exger.2020.110875

Nasruddin, N. I., Saimin, J., & Tosepu, R. (2022). Korelasi indeks massa tubuh terhadap rasio trigliserida dan high-density lipoprotein-cholesterol pada wanita usia subur dengan obesitas. Jurnal Gizi Klinik Indonesia, 18(3), 126. https://doi.org/10.22146/ijcn.69245

Procaccini, C., de Candia, P., Russo, C., De Rosa, G., Lepore, M. T., Colamatteo, A., & Matarese, G. (2023). Caloric restriction for the immunometabolic control of human health. Cardiovascular Research, 119(18), 2787–2800. https://doi.org/10.1093/cvr/cvad035

Putri, S. A., Arini, S. Y., Atmaka, D. R., Kusuma, A. R., Rahmawati, A. F., Wijanarko, M. A. V., Nor, N. M., & Shahid, N. S. M. (2025). Very Low Calorie Diets Affect Long Term Weight Loss and Health Outcomes: a Systematic Review. Indonesian Journal of Public Health, 20(1), 187–199. https://doi.org/10.20473/ijph.v20i1.2025.187-199

Rizkawati, M., Kedokteran, F., & Indonesia, U. I. (2022). POTENSI DIET SOYBEAN ( GLYCINE MAX ) Fakultas Kedokteran , Universitas Islam Indonesia. 5(April), 40–50.

Sears, B., & Saha, A. K. (2021). Dietary Control of Inflammation and Resolution. Frontiers in Nutrition, 8(August), 1–19. https://doi.org/10.3389/fnut.2021.709435

Setyawati, R., & Lasroha, M. (2021). Overview of HDL , LDL , Triglycerides , and Total Cholesterol in Obese Patients. Advances in Health Sciences Research, 39(SeSICNiMPH), 12–14.

Shobako, N., Shimada, H., Yamato, T., Nakazeko, T., Hirano, Y., Nakamura, F., & Honda, K. (2024). Visceral Fat-Reducing Effect of Novel Dietary Intervention Program: A Randomized Controlled Trial in Japanese Males. Nutrients , 16(18). https://doi.org/10.3390/nu16183202

Sukkar, S. G., & Muscaritoli, M. (2021). A Clinical Perspective of Low Carbohydrate Ketogenic Diets: A Narrative Review. Frontiers in Nutrition, 8(July), 1–15. https://doi.org/10.3389/fnut.2021.642628

Tan, S. T., Tan, S. S., & Tan, C. X. (2023). Soy protein, bioactive peptides, and isoflavones: A review of their safety and health benefits. PharmaNutrition, 25(May), 100352. https://doi.org/10.1016/j.phanu.2023.100352

Volpp, K. G., Berkowitz, S. A., Sharma, S. V., Anderson, C. A. M., Brewer, L. C., Elkind, M. S. V., Gardner, C. D., Gervis, J. E., Harrington, R. A., Herrero, M., Lichtenstein, A. H., McClellan, M., Muse, J., Roberto, C. A., & Zachariah, J. P. V. (2023). Food Is Medicine: A Presidential Advisory from the American Heart Association. Circulation, 148(18), 1417–1439. https://doi.org/10.1161/CIR.0000000000001182

Wang, Y., Qi, W., Song, G., Pang, S., Peng, Z., Li, Y., & Wang, P. (2020). High-fructose diet increases inflammatory cytokines and alters gut microbiota composition in rats. Mediators of Inflammation, 2020. https://doi.org/10.1155/2020/6672636

Zare, R., Devrim-Lanpir, A., Guazzotti, S., Ali Redha, A., Prokopidis, K., Spadaccini, D., Cannataro, R., Cione, E., Henselmans, M., & Aragon, A. A. (2023). Effect of Soy Protein Supplementation on Muscle Adaptations, Metabolic and Antioxidant Status, Hormonal Response, and Exercise Performance of Active Individuals and Athletes: A Systematic Review of Randomised Controlled Trials. In Sports Medicine (Vol. 53, Issue 12). Springer International Publishing. https://doi.org/10.1007/s40279-023-01899-w

Zheng, H. (2025). Lipid Profiling in Obesity: The Limitations of the Friedewald Equation. American Journal of Medicine, 138(2), 172–174. https://doi.org/10.1016/j.amjmed.2024.09.011

Zhu, J., Zhao, Q., Qiu, Y., Zhang, Y., Cui, S., Yu, Y., Chen, B., Zhu, M., Wang, N., Liu, X., Jiang, Y., Xu, W., & Zhao, G. (2021). Soy isoflavones intake and obesity in chinese adults: A cross-sectional study in Shanghai, China. Nutrients, 13(8), 1–14. https://doi.org/10.3390/nu13082715

DOI: http://dx.doi.org/10.30867/gikes.v7i1.3083

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