Efek suplementasi kombinasi bawang putih, jahe merah, dan beras ragi merah (BJR-22) terhadap kadar kolesterol LDL pasien stroke dengan dislipidemia

Author(s): Lieliesnaini Octaviariani Sutoyo, Rihadatul Aisy, Dicky Rinaldi, Retnaningsih Retnaningsih, Santoso Jaeri
DOI: 10.30867/gikes.v5i1.1301

Abstract

Background: Stroke is the second leading cause of death worldwide, a significant contributor to disability, and the leading cause of stroke prevention by controlling risk factors. Dyslipidemia is a high risk of plaque buildup in the cell wall. An alternative search must be performed to prevent recurrent stroke events and to improve survival without disability. Nutraceuticals such as garlic (Allium sativum), red ginger (Zingiber officinale Roxb. var. rubrum Rosc.), and red yeast rice (Monascus purpureus) contain active compounds that inhibit HMG-CoA activity and limit the rate of cholesterol synthesis.

Objectives: To analyze the effect of red ginger, garlic, and red yeast rice on low-density lipoprotein cholesterol (LDL-C) levels in ischemic stroke patients with dyslipidemia.

Methods: Quasi-experimental research was conducted in a double-blinded manner. The study was conducted on outpatients at the Neurology Clinic of Dr. Kariadi Hospital Semarang, Central Java, from September to December 2022. Forty subjects with ischemic stroke and dyslipidemia were divided into intervention (20 subjects) and control (20 subjects) groups using consecutive sampling techniques. The intervention was conducted for 30 days. The intervention group received supplementation with a combination of garlic 225 mg, red ginger 125 mg of red ginger, 250 mg of 3x/day and statin for 30 days, while the control group received a placebo and statin. Lipid profile measurements were conducted at the Central Lab of Dr. Kariadi Hospital, Semarang, India. Data were analyzed using Fisher-Exact, Wilcoxon, and paired t-tests at a 95% CI.

Results:  The average LDL level before intervention was 152,0 ± 58,54, and after the intervention was 89,0 ± 27,07 (mg/dL). Before the intervention, The intermediate cholesterol level was 207,6 ± 37,6 to 164,5 ± 45,58. There was a significant improvement in LDL-C (p= 0,000) and cholesterol (p= 0,001).

Conclusion: Supplementation with a combination of garlic, red ginger, and red yeast rice is effective in reducing  LDL cholesterol levels

Keywords

Bawang putih, Jahe merah, Beras ragi merah, Kolesterol LDL

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References

Abdu, H., & Seyoum, G. (2022). Sex Differences in Stroke Risk Factors, Clinical Profiles, and In-Hospital Outcomes Among Stroke Patients Admitted to the Medical Ward of Dessie Comprehensive Specialized Hospital, Northeast Ethiopia. Degenerative Neurological and Neuromuscular Disease, Volume 12(October), 133–144. https://doi.org/10.2147/dnnd.s383564

Al Rahmad, A. H. (2021). Hubungan Indeks Massa Tubuh dengan Kolesterol, LDL, dan Trigliserida pada Pasien Jantung Koroner di Kota Banda Aceh. Jurnal Kesehatan, 9(1), 1–8. https://doi.org/10.25047/jkes.v9i1.161

Arsana, P. M., Rosandi, R., Manaf, A., Budhiarta, A., & Hikmat Permana. (2019). Pedoman pengelolaan dislipidemi di Indonesia 2019. In Pb. Perkeni (p. 9). https://doi.org/10.1002/bit.22430

Chan, W. J., Mclachlan, A. J., Luca, E. J., & Harnett, J. E. (2019). Garlic ( Allium sativum L .) in the management of hypertension and dyslipidemia – A systematic review. Journal of Herbal Medicine, July, 100292. https://doi.org/10.1016/j.hermed.2019.100292

Cicero, A. F. G., Fogacci, F., & Banach, M. (2019). Red Yeast Rice for Hypercholesterolemia. Methodist DeBakey Cardiovascular Journal, 15(3), 192–199. https://doi.org/10.14797/mdcj-15-3-192

Fakhri, Z., Shab-Bidar, S., Firoozi, S., & Djafarian, K. (2018). The Effects of Ginger Supplementation on Lipid Profile: A Meta-Analysis of Randomized Clinical Trials. Herbal Medicines Journal, 3(3), 120–151.

Francini-pesenti, F., Rossi, A., Rocchi, V., Martini, C., Francini-pesenti, C. A. F., & Unit, C. N. (2017). Red Yeast Rice in the Long-Term Treatment of Hypercholesterolemia . A Single-Center Experience. 1(3), 16–18.

Gao, H., Guan, T., Li, C., Zuo, G., Yamahara, J., Wang, J., & Li, Y. (2012). Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: Modulation of the hepatic carbohydrate response element-binding protein-mediated pathway. Evidence-Based Complementary and Alternative Medicine, 2012. https://doi.org/10.1155/2012/570948

Gerards, M. C., Terlou, R. J., Yu, H., Koks, C. H. W., & Gerdes, V. E. A. (2015). Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - A systematic review and meta-analysis. Atherosclerosis, 240(2), 415–423. https://doi.org/10.1016/j.atherosclerosis.2015.04.004

Hawkins, B. T., Brown, R. C., & Davis, T. P. (2002). Smoking and ischemic stroke: A role for nicotine? Trends in Pharmacological Sciences, 23(2), 78–82. https://doi.org/10.1016/S0165-6147(02)01893-X

Ivan, I., Wreksoatmodjo, B. R., & Darmawan, O. (2019). Hubungan Antara Riwayat Penyakit Jantung Dengan Tingkat Keparahan Stroke Iskemik Akut Pertama Kali. Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia, 37(1), 48–53. https://doi.org/10.52386/neurona.v37i1.101

Kheirmandparizi, M. et al. (2021). Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta-analysis of randomised clinical trials. The International Journal of Clinical Practice. https://doi.org/https://doi.org/10.1111/ijcp.14974

Laily, R. S. (2017). Hubungan Karakteristik Penderita dan Hipertensi dengan Kejadian Stroke Iskemik. Jurnal Berkala Epidemiologi, 5(1), 48–59. https://doi.org/10.20473/jbe.v5i1.

Li, P., Wang, Q., Chen, K., Zou, S., Shu, S., Lu, C., Wang, S., Jiang, Y., Fan, C., & Luo, Y. (2022). Red Yeast Rice for Hyperlipidemia: A Meta-Analysis of 15 High-Quality Randomized Controlled Trials. Frontiers in Pharmacology, 12(January), 1–13. https://doi.org/10.3389/fphar.2021.819482

Liena, S. D. D. R. (2019). Hypertension and Diabetes Mellitus Increase the Risk of Stroke (pp. 147–152). Jurnal Kesehatan Masyarakat.

Mulyani, N. S., AL Rahmad, A. H., & Jannah, R. (2018). Risk factors for blood cholesterol levels in outpatients with coronary heart disease in Meuraxa hospital. AcTion: Aceh Nutrition Journal, 3(2), 132–140. https://doi.org/10.30867/action.v3i2.113

Murad, S., Niaz, K., & Aslam, H. (2018). Effects of Ginger on LDL-C, Total Cholesterol and Body Weight. Clinical & Medical Biochemistry, 04(02), 4–6. https://doi.org/10.4172/2471-2663.1000140

Mushtaq, S. (2018). Effect of Dried Ginger (Zingiber officinale) on Serum Total Cholesterol Level in Hyperlipidemic Patients. Annals of King Edward Medical University, 24(4), 918–921.

Nadhifah, T. A., & Sjarqiah, U. (2022). Gambaran Pasien Stroke Pada Lansia di Rumah Sakit Islam Jakarta Sukapura Tahun 2019. Muhammadiyah Journal of Geriatric, 3(1), 23. https://doi.org/10.24853/mujg.3.1.23-30

Onwuchekwa, A. C., Tobin-West, C., & Babatunde, S. (2014). Prevalence and risk factors for stroke in an adult population in a rural community in the Niger Delta, South-South Nigeria. Journal of Stroke and Cerebrovascular Diseases, 23(3), 505–510. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.04.010

Opoku, S., Gan, Y., Fu, W., Chen, D., Addo-yobo, E., & Trofimovitch, D. (2019). Prevalence and risk factors for dyslipidemia among adults in rural and urban China : findings from the China National Stroke Screening and prevention project ( CNSSPP ). BMC, 13, 1–15.

Pohanka, A., Normark, S., Bergman, P., Linde, C., Pu, K., & Bjo, L. (2011). Studies on the Antibacterial Effects of Statins - In Vitro and In Vivo. Plos ONe, 6(8), 1–7. https://doi.org/10.1371/journal.pone.0024394

Pol T, Held C, Westerbergh J, Lindbäck J, et. al. (2018). Dyslipidemia and risk of cardiovascular events in patients with atrial fibrillation treated with Oral anticoagulation therapy: insights from the ARISTOTLE (Apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation) trial. J Am Heart Assoc, 7(3), 1–11.

Pourmasoumi, M., Hadi, A., Rafie, N., Najafgholizadeh, A., Mohammadi, H., & Rouhani, M. H. (2018). The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials. Phytomedicine, 43, 28–36. https://doi.org/10.1016/j.phymed.2018.03.043

Pramitasari, M. R., Riana, R., & Bahrudin, M. (2012). Pengaruh Ekstrak Bawang Putih (Allium sativum L) terhadap Perbaikan Profil Lipid pada Rattus Norvegicus Strain Wistar. Jurnal Sains Medika, 8(2), 85–96.

Ri, K. (2013). Riset Kesehatan Dasar; RISKESDAS.

Balitbang Kemenkes RI.

Suhandini, T., Widyaningsih, H., Alvita, G. W., & Hartini, S. (2022). Gambaran Status Gizi pada Pasien Stroke Non Hemoragik di Poliklinik Syaraf Rsud Dr. R Soetrasno Rembang. Jurnal Keperawatan Dan Kesehatan Masyarakat Cendekia Utama, 11(2), 164–173.

Watila, M., Nyandaiti, Y., Bwala, S., & Ibrahim, A. (2011). Gender variation in risk factors and clinical presentation of acute stroke, Northeastern Nigeria. Journal of Neuroscience and Behavioural Health, 3(3), 38–43.

WHO. (2016). Global Health Observatory data repository. World Health Organization.

DOI: http://dx.doi.org/10.30867/gikes.v5i1.1301

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